Start a new simulation

Select the workflow by the type of input you have.

Recommended

Protein–ligand complex

Use a PDB containing the protein and bound ligand. The system inspects and repairs the structure first, then continues through ligand parameterisation and MD.

Upload complex PDB
Special case

Protein only

Use only when you intentionally want an apo-protein simulation without a ligand.

Open protein-only wizard
Advanced

Prepared TPR

Use only when the complete GROMACS input has already been prepared and validated elsewhere.

Run prepared input
For JZ4 and other bound compounds: choose Protein–ligand complex. Do not use the protein-only wizard.